Endocrine Abstracts

A 22 years old woman presented with a few days history of nausea, vomiting and general lethargy. She was not on any treatment except the oral contraceptive pill (OCP). She was apyrexial, tachycardic at 140/min with a regular pulse and her blood pressure was 110/70. She was not pigmented. Her plasma sodium was 131 mmol/l, with normal potassium, creatinine and urea. Her arterial blood gas analysis showed a pH of 7.22 and bicarbonate of 12mmol/L. Her TFTs showed a thyrotoxic pict...

A 61 year old woman presented with a six months history of nausea, vomiting and lethargy. She is a non-smoker and drinks little alcohol. She was on 100mcg of Thyroxine following partial thyroidectomy. Physical examination was unremarkable apart from postural hypotension (BP 140/80mmHg laying, 105/75mmHg standing). Blood tests showed plasma sodium of 121mmol/L with normal potassium, urea, creatinine, FBC, random glucose and TFTs. A short synacthen test (1mcg) was normal with a ...

Introduction: Chronic excess of growth hormone is responsible for numerous cardiovascular, respiratory, metabolic and neoplastic complications, leading to significant morbidity and mortality. The aim of this study is to analyze the different cardiovascular manifestations and cardiovascular risk factors in acromegaly.Methods: A retrospective descriptive study including 44 patients hospitalized in the endocrinology department of University Hospital Mohamed...

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder of uncertain aetiology, affects 1 in 10 reproductive women and has broad spectrum risks related to reproductive, cardiometabolic and psychosocial health. The wide overlap with other hyperandrogenemic conditions, complexity of PCOS spectrum, and inconsistencies in investigation and management potentially can result in risks of delay in diagnosis and management.Aim: To evaluate ...

Introduction: The COVID pandemic was a challenge in terms of physiopathology and therapeutics. Diabetics represent more than 40% of patients hospitalized for COVID. There was many new cases of diabetes declared during or after a COVID. The purpose of this report is to raise the link between Sars-Cov-2 infection and the appearance of glycemic disorders and new cases of diabetes.Case Presentation 1: A 28-years-old man who had a serious COVID-19 a month ago...

Introduction: Diabetic osteoarthropathy (D.O) commonly referred to as Charcot’s foot is a complication secondary to neuropathic and inflammatory osteolysis, occurring in a setting of old and/or poorly controlled diabetes. Its pathophysiology remains poorly understood and its diagnosis must be systematically evoked in the presence of any inflammatory sign that localised to the foot or ankle occurring on a background of diabetic neuropathy.Clinical ca...

Introduction: Sinonasal neuroendocrine carcinoma SNECs are a rare group of neoplasms that account for only 5% of all sinonasal malignancies. SNECs are categorized by their differentiation grade into well-, moderately- and poorly differentiated.Case report: We describe a classical case of SNEC with secondary orbital involvement in a 34-year-old male patient presented of the occurrence of a right epistaxis. First of all, the patient is smoking. The beginni...

The Fibroblast Growth Factor 23 (FGF23) gene provides instructions for making a protein called FGF23. This protein is necessary in regulating the phosphate levels within the body. We present a case of an adult Caucasian man with persistent hypophosphatemia due to mutation in ENPP1.Case History: A 34 years old male presented with intermittent muscle pain, cramps and headaches. He also noticed episodic breathlessness and irritability. He had no hi...

The co-existence of thyrotropin (TSH) and growth hormone (GH) secreting pituitary adenoma is exceedingly rare. Less than 15 cases having been reported.Case report: A 75 years’ old man presented with new-onset atrial fibrillation. He had high FT4 with normal TSH. His ultrasound scan of the neck showed a solitary nodule. He had ablation twice and was started on bisoprolol and anticoagulant. He had an MRI scan for headaches and this showed a pituitary ...

Background: Von Hippel-Lindau disease (VHL) is an autosomal dominant disease, characterized by haemangioblastomas of the retina and CNS, renal cell carcinomas (RCC) and renal cysts, pheochromocytomas, pancreatic neuroendocrine tumors and cysts, and endolymphatic sac tumors. VHL is associated with a germline mutation of the VHL tumor suppressor gene on the short arm of chromosome 3. The type-1 disease is caused by mutations, leading to severe disruption of protein acti...